Standard and Molecular NOAELs for Rat Testicular Toxicity Induced by Flutamide
نویسندگان
چکیده
منابع مشابه
Efficiency of naringin against reproductive toxicity and testicular damages induced by bisphenol A in rats
Objective(s): Bisphenol A (BPA) as a synthetic compound is applied in many plastic industries. BPA has been reported to have endocrine-disrupting feature with cytotoxic effects. The study aimed to evaluate the efficiency of Naringin against testicular toxicity induced by BPA in adult rats.Materials and Methods: The animals were assigned into six groups of control, BPA-treated (50 mg/kg), BPA+Na...
متن کاملDexrazoxane exacerbates doxorubicin-induced testicular toxicity.
Infertility induced by anti-cancer treatments pose a major concern for cancer survivors. Doxorubicin (DXR) has been previously shown to exert toxic effects on the testicular germinal epithelium. Based upon the cardioprotective traits of dexrazoxane (DEX), we studied its potential effect in reducing DXR-induced testicular toxicity. Male mice were injected with 5 mg/kg DXR, 100 mg/kg DEX, combi...
متن کاملTesticular toxicity of thiram in rat: morphological and biochemical evaluations.
Tetramethylthiuram disulphide (Thiram), a dithiocarbamate fungicide was administered to male rats through gavage at dose 5, 10 and 25 mg/kg/day for 30, 60 and 90 days. A significant increase in relative testes weight (GSI) was observed at dose (25 mg/kg/d) after 90 days exposure, associated with mild pathomorphological changes. This included degeneration of seminiferous tubules with sloughing o...
متن کاملSaussurea Costus Extract Has Anti-inflammatory, Antioxidant, and Hormonal Effects Against Testicular Toxicity Induced by Oxaliplatin in Male Albino Rats
Background: Testicular dysfunction is one of the common side effects that results from the treatment with oxaliplatin® as a chemotherapy drug, and pharmaceutical search for agents to relieve the side effects are underway. The current study explored the possible ameliorative and regenerative effects of Costus ethanolic extract against testicular degeneration in male rats induced by oxaliplatin. ...
متن کاملProtein expression analysis of rat testes induced testicular toxicity with several reproductive toxicants.
The utilization of safety biomarkers to predict the possibility of compound-related toxicity provides several advantages for drug discovery and development, especially at an early stage. The objectives of this study were to investigate the effects of male reproductive toxicants on protein expression profiles in the rat testes and to identify potential biomarker candidates. Four well-known repro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2009
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfp056